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Version 2.0.2

  • NA related C code bug fix related to gcc compilers

  • Add documentation for better clarity and user guidance

Version 2.0.1

CRAN release: 2023-04-18

  • Bug fix when K=1 in mams.sim
  • Add src/init.c file

Version 2.0.0

CRAN release: 2022-01-14

  • Parallelisation framework included for several functions
  • Recoding of parts of the functions in C
  • Inclusion of new package help file
  • Update of authors

Version 1.4.2

CRAN release: 2021-06-16

  • Fixed an error in tite.mams
  • Update of author contact information

Version 1.4.1

CRAN release: 2020-11-20

  • Minor bug fix

Version 1.4

CRAN release: 2020-11-17

  • Adjusted code to also provide answers for K=1 and J=1
  • Fixed an error in tite.mams
  • added warning to show that sample size search stopped due to maximum reached

Version 1.3

CRAN release: 2019-01-25

  • References updated

Version 1.2

CRAN release: 2017-09-14

  • New function ‘ordinal.mams’ for ordinal and binary endpoints
  • New function ‘tite.mams’ for time-to-event endpoints
  • Effect sizes can be specified on traditional or probability scale
  • Search for sample size is capped at a maximum value
  • Harmonised function and input names (most notably, ‘step_down_mams’ and ‘update_mams’ are now called ‘stepdown.mams’ and ‘stepdown.update’)
  • Corrected minor bugs in ‘mams’

Version 1.1

  • Corrected minor bug in mams.sim for K=1

Version 1.0

CRAN release: 2016-07-19

  • Altered mams function to improve consistency for different allocation ratios

Version 0.9

CRAN release: 2016-06-14

  • Corrected a bug in update_mams

Version 0.8

CRAN release: 2016-05-17

  • Removal of some depreciated code

Version 0.7

CRAN release: 2015-11-04

  • Modified print and summary to only return integer sample sizes
  • Updated mams function to deal with minor inconsistency when J=1

Version 0.6

CRAN release: 2015-09-29

  • Corrected a bug in new.bounds
  • Corrected a bug in mams.sim
  • A few minor bugs in the plot functions corrected
  • Arguments bty and las for the plot functions added
  • Inconsistencies in the documentation removed

Version 0.5

CRAN release: 2015-06-24

  • A bug in function mams.sim corrected

Version 0.4

CRAN release: 2015-02-28

  • A bug in function mams corrected

Version 0.3

CRAN release: 2014-05-07

  • New function (step_down_mams) to calculate stopping boundaries for all intersection hypothesis tests in a closed testing procedure.
  • New function (update_mams) to update boundaries at an interim analysis to take account of unplanned treatment selection and/or sample size reestimation.
  • Documentation updated

Version 0.2

CRAN release: 2012-05-28

  • New function (mams.sim) to simulate mams studies included
  • New function (new.bounds) to update boundaries based on observed number of observations included
  • Citation information updated
  • Output data.frame of function mams generalized
  • Additional option to supress sample size calculation included in function mams
  • Documentation updated

Version 0.1

CRAN release: 2012-04-25

  • Initial release